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There are a wide range of clinical manifestations associated with APDS, and the condition can present differently from patient to patient.1,2
Clinical manifestations of APDS can appear in childhood, from as early as one year old, and become progressively worse over time.1,2 Patients with APDS often experience a variety of acute and chronic clinical features across multiple organ systems.1,2
Research suggests that people with APDS frequently suffer from the following complications:5
92%
86%
53%
50%
35%
Research has suggested that APDS leads to early mortality, due to an accumulation of complications caused by APDS.4,6 Benign lymphoproliferation can progress to malignancy in patients with APDS, with lymphomas being the most common form.2 It is estimated that there is a 78% cumulative risk for lymphoid malignancy at 40 years of age.2
42%
of APDS fatalities are thought to be due to lymphoma.7
As well as living with recurrent and progressive manifestations, patients with APDS often require regular medical intervention, surgeries, outpatient appointments and hospital admissions.2,6,8,9 Along with the physical symptoms, APDS can have a negative impact on mental health, with many patients experiencing stress, anxiety and depression.6,8-12 Furthermore, it takes an average of seven years to be diagnosed with APDS, which can exacerbate feelings of anxiety and depression.1,9